White Papers

CDMO Service

Isolation, expansion, transduction, and production of endothelial-cord derived working cell bank and blood stem cell transplantation final product in support of phase I-III clinical trials in malignancy

cGMP Cell Manufacturing

A new cell therapy manufacturing methodology needed to be tech transferred to Excellos manufacturing teams in a relatively short timeline as part of initiation of Phase I and Phase II clinical trials with the product.
manufacturing process, TIL therapies applications

Non-Proliferation assay

Confirming Feeder Cells for TIL Expansion Are Suitable for Phase II Clinical Trials and Beyond

Adverse Impact of NH₄Cl-Based Erythroreduction on T Cells

Standard NH₄Cl erythroreduction protocols significantly impair T cell metabolic fitness and phosphorylation (30-40% reduction) despite normal viability metrics, revealing critical blind spots in current cell therapy quality control.

T Cell Memory Variability in Healthy Allogeneic Donors

Tn/scm memory content varies dramatically across healthy donors and decreases non-linearly with age, while standard expansion protocols further reduce these critical cells essential for durable therapeutic responses.

A researcher wearing blue nitrile gloves holds five Excellos sample vials with orange caps, containing various isolated immune cells including CD56+ T Cells, CD34+ cells, CD3+ T Cells, and Gamma Delta T cells. Each vial is clearly labeled with product codes and research use designation

CMC Consultation Services for Cell Therapy Developers

Excellos offers free 60-minute CMC strategy consultations for early-stage cell therapy developers, addressing critical regulatory and manufacturing decisions before they become costly bottlenecks in IND filings and clinical timelines.d

Smart Selection of Leukapheresis Starting Material and Continuous Process Improvement for iPBMC Manufacturing

Tumor-infiltrating leukocytes (TILs) are a promising autologous immunotherapeutic due to priorantigenic stimulation and ability to navigate tumor microenvironment (TMEs).