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General Description
Human CD3+ Gamma Delta T Cells are a unique subset of T cells that play an important role in both innate and adaptive immunity. They are found in low numbers in peripheral blood, but are more abundant in mucosal tissues such as the gut, skin, lungs, and uterus. CD3+ Gamma delta T cells are capable of rapidly responding to a variety of stimuli, including stress proteins, phosphoantigens, and microbial products. They can also recognize and kill tumor cells.
Technical Description
Gamma delta T cells are characterized by their expression of the CD3 surface protein and a gamma delta T cell receptor (TCR). The gamma delta TCR is different from the alpha beta TCR expressed by conventional T cells in that it does not recognize peptide antigens presented by MHC molecules. Instead, CD3+ gamma delta T cells recognize a variety of non-peptide antigens, including stress proteins, phosphoantigens, and microbial products.
Gamma delta T cells can be activated by a variety of stimuli, including cytokines, TLR ligands, and direct interaction with target cells. Once activated, gamma delta T cells can secrete a variety of cytokines, including IFN-γ, TNF-α, and IL-17, which help to orchestrate the immune response. Gamma delta T cells can also directly kill infected cells and tumor cells through a variety of mechanisms, including cytotoxicity and antibody-dependent cell-mediated cytotoxicity (ADCC).
Product Use Examples
Gamma delta T cells are used in a variety of research and clinical applications, including: immunology research, cellular therapy and vaccine development.
Excellos 360 employs Excellos’s deep cell characterization approach to goes deeper than typical cell and donor screening to create a comprehensive immune cell profile for each donor, as well as an assessment of the metabolic and effector potential of their cells that looks beyond surface markers. Learn More about Excellos 360 Here
