Single-Cell Analysis of T Cells – Improved Prediction of Disease Risk

Single-Cell analysis T-Cells Excellos Blog

The La Jolla researchers are studying how small changes in gene expression can influence the function of immune cells during infection. Single-cell analysis was performed on activated CD4+ T cells from 89 healthy donors. It turns out that the old adage of “one gene, one protein” is not precisely true. In reality, as research on […]

Stem Cell Transduction Efficiency – Managing Donor Variance

Managing Donor Variance in Stem Cell Transduction Efficiency

Gene therapy, and in particular, therapy involving genetically modified stem cells, is one of the most promising methods for treating genetic disease and defects, and has therefore become a popular focus of research and development. In recent years, using adenoviral vectors to deliver modified genes has become standard practice. Adeno-associated viruses (AVVs) are easy to […]

Single-Cell Immune Profiling Reveals Remarkable Changes Associated with COVID-19

single-cell immune profiling reveals immune changes associated with COVID-19

Researchers at the La Jolla Institute for Immunology cite using Excellos sourced healthy donor starting material to carry out single-cell immune profiling for their research on severe COVID-19. [1] Great strides have been made in fighting the SARS-CoV-2 virus, the most noteworthy being the development and distribution of the COVID-19 vaccine. However, we must keep […]

Trogocytosis – A Case of T cell Identity Theft Offers Essential Clue to Solving MS

Trogocytosis - A Case of T-cell Identity Theft

A case of immune T cell identity theft (trogocytosis) gave German scientists the vital clue they needed to understand a key mechanism behind the development of multiple sclerosis (MS). In a recently published paper, scientists at the Institute of Neuropathology in Gottingen, Germany, describe new research that could help doctors treat MS. [1] The key […]

Efficient Isolation of Antigen-Specific B Cells

Efficient Isolation of Antigen-Specific B Cells

Scientists at Scripps Research Center in La Jolla are working to streamline monoclonal antibody vaccine development by devising more efficient ways to screen for rare B antigen-specific B cells. [1] Today, monoclonal antibodies (mAbs) are at the forefront of vaccine research as scientists continue to develop new treatments to fight cancer, autoimmunity, and infectious disease. […]

Cancer Immunotherapy – High Precision & Remote-Controlled

High Precision Remote-Controlled Cancer Immunotherapy

Researchers at UCSD and Memorial Sloan Kettering Cancer Center used Excellos healthy donor starting material to carry out a fascinating study on ultrasonic activation of cancer immunotherapy. CAR-T cell therapy is a paradigm shifting therapeutic with the potential to have an immense impact on cancer treatment options. The number of CAR-T therapies in clinical trial […]

NK cell therapy – Excellos Cells Aid Discovery of Key Cancer Killing Target

NK cell therapy holds the promise of new therapeutics for underserved cancer indications

NK cell therapy holds the promise of new therapeutics for underserved cancer indications. A recent publication in Nature Communications uses Excellos sourced cellular starting materials for research on the mechanisms behind NK cell cytotoxicity. [1] The capacity for cancer cells to avoid immune detection is notorious. Normally, cells that are faulty, diseased, or reaching the […]

Allogeneic CAR-T Study – Healthy Donor Cells Outperform Patient Cells in Cancer Therapy

Allogeneic CAR-T Study - Healthy Donor Cells Outperform Patient Cells in Cancer Therapy

A new Allogeneic CAR-T study has shown CAR-T cells derived from healthy donors to be superior at fighting cancer compared to CAR-T cells derived from patients. [1] In a press release, biotechnology company Allogene Therapeutics announced preclinical results from their study on the treatment of multiple myeloma using allogeneic CAR-T cell therapy. Multiple myeloma is […]

Effective Solutions to Cell Therapy Supply Chain & Logistics

Cell Therapy Supply Chain & Logistics

Where the Cell Therapy industry is facing an ever-growing complexity in supply chain and logistics, now is the time to optimize the cell therapy supply chain to create a dependable supply of cellular therapeutics. Adam Clark, Director of Commercial Operations here at Excellos recently attended the Supply Chain & Logistics for Cell Therapies Summit in […]

Cell Therapies – Building Solid Foundations for Success

Building Solid Foundations for Successful Cell Therapies

Raw material experts Dr. David Wellis and Dr. Robert Tressler want to share their knowledge on how to select and source cellular starting materials that build the foundations of successful cell therapies. Dr. Wellis and Dr. Tressler are life sciences experts; both boast decades of experience at the forefront of biomedical research and technology. Mere […]